Exit from the airport to I-40 west toward Durham taking the Durham Freeway west (Hwy 147) into the city. From the Durham Expressway, take the DUKE STREET exit (one-way north) which leads to Hwy 501 north. Follow Hwy 501 north to South Boston, approximately 60 miles.
From South Boston, take Hwy. 501 south to Durham, NC, by way of the 501-Bypass into the city. Key landmarks passed include the crossing of I-85 , pass Northgate Shopping Center (on right), at which point you are on Gregson Street (one-way south through Durham). Other landmarks passed include the Durham High School on the left and Brightleaf Square Shopping Center (an old restored tobacco warehouse) on the right. You will also cross railroad tracks and the Durham Freeway just prior to making a left-hand exit (approximately one block) onto Hwy. 147 to the Durham Freeway east to I-40 and Raleigh-Durham Airport.
Copyright 2003 by the Town of South Boston, Virginia